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eCM Meeting Abstracts 2014, Collection 4

eCM XV - Cartilage & Disc: Repair and Regeneration
June 16-18, 2014, Convention Centre, Davos Platz, Switzerland

Abstracts of the meeting

All abstracts: click here to download all the abstracts in one file

Oral presentations, followed by Posters

Page 1: PJ Roughley
The life of aggrecan

Page 2: CW Archer
The regenerative potential of articular cartilage

Page 3: AA Pitsillides
Transcriptional profiling in osteoarthritis

Page 4: LB Creemers
Cytokine profiles and pathways in trauma and degeneration

Page 5: Z Kazezian, R Gawri, L Haglund, J Ouellet, F Mwale, A Pandit, M Alini, S Grad
Identification of disc degeneration markers in the human AF by microarray

Page 6: B Ranera, C O’Flatharta, G McKenna, T Jungwirth, G Shaw, L Howard, WW Cruikshank, M Tuzova, M Leijs, GJVM van Osch, F Barry, JM Murphy
Interleukin 16 in control of proliferation of mesenchymal stem cells (MSC), in MSC chondrogenesis and in early osteoarthritis

Page 7: D Chen
The role of β-catenin signalling in cartilage

Page 8: C Little
Pre-clinical models of inter-vertebral disc disease (IVDD): can we learn from the new paradigms of organ-wide pathology and disease phenotypes in osteoarthritis?

Page 9: MP Grant, LM Epure, J Antoniou, F Mwale
Human cartilaginous endplate degeneration is regulated by the extracellular calcium-sensing receptor

Page 10: SJ Gilbert, C Bonnet, M Davies, C Elford, LB Meakin, VC Duance, DJ Mason, EJ Blain
Establishment and characterisation of a non-invasive model of post-traumatic knee osteoarthritis

Page 11: G Marfia, SE Navone, C Di Vito, L Giammattei, M Egidi, M Zavanone, P Rampini, L Riboni, R Campanella
Human adipose mesenchymal stromal cells transplantation promotes intervertebral disc regeneration in Biglycan-deficient murine model of chronic and progressive disc degeneration

Page 12: CT Hung, TN Kelly, SR Sampat, GA Ateshian
Chondrocyte mechanobiology: applications to cartilage tissue engineering

Page 13: NC Nowlan
Developmental biomechanics of the prenatal skeleton

Page 14: TH Smit, K. Emanuel, PP Vergroessen, KP Paul, AJ van der Veen, I Kingma
Mechanics and biology of the intervertebral disc: long-term studies in a Loaded Disc Culture System

Page 15: RL Trevino, CA Pacione, S Chubinskaya, AM Malfait, MA Wimmer
Articulation reduces IL-1β effect on cartilage biosynthesis and matrix degradation

Page 16: AKT Wann, CL Thompson, EM Tan, MM Knight
Chondrocyte de-differentiation is associated with primary cilia elongation and a reduced capacity for hedgehog signalling

Page 17: DH Rosenzweig, TM Quinn, L Haglund
Low-frequency high-magnitude mechanical strain of articular chondrocytes activates p38 MAPK and induces phenotypic changes associated with osteoarthritis and pain

Page 18: SI Stupp
Biomimetic and bioactive scaffolds for regeneration

Page 20: M Likhitpanichkul, Y Kim, Z Kazezian, A Pandit, AC Hecht, JC Iatridis
Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-TNFα drug

Page 21: IL Mohd-Isa, D Tiernan, A Srivastava, P Rooney, A Pandit
A Therapeutic Effect of Hyaluronic Acid Based-Hydrogels in In Vitro Inflammation Model of Nucleus Pulposus

Page 22: F Babaei, J Parry, P Kok, S Kakar, YW Lam, MJ Yaszemski, M Dadsetan
Osteochondral defect repair using a biomimetic hydrogel

Page 23: S Kimber, A Cheng, Z Kapacee, P Nimkingratana, R Griffiths, T Wang, M Ronshaugen, TE Hardingham
Pluripotent stem cells for cartilage repair

Page 24: F Guilak
Engineering new biologic therapies for osteoarthritis

Page 25: B Schminke, H Muhammad, G Cingöz, C Bode, S von der Heyde, N Miosge
Manipulation of chondrogenic progenitor cells from late stages of osteoarthritis for cartilage repair

Page 26: J Fischer, A Aulmann, V Dexheimer, T Grossner, W Richter
Intermittent but not continuous parathyroid hormone-related protein exposure augments mesenchymal stromal cell chondrogenesis and reduces hypertrophy via cAMP/PKA signalling

Page 27: F Cai, X-T Wu, X-H Xie
Evaluation of bone marrow mesenchymal stem cell (MSCs)-based intervertebral disc regeneration using quantitative T2 mapping: a study in a rabbit model

Page 28: AR. Armiento, F Dell’Accio, C De Bari
A mouse model of joint surface injury: Contribution of functional mesenchymal stem cells to cartilage repair

Page 29: GJVM van Osch, PK van der Kraan, YM Bastiaansen-Jenniskens
Inflammation and cartilage regeneration

Page 30: MV Risbud
Emerging role of PHDs in intervertebral disc degeneration and inflammation

Page 31: O Krupkova, M Sekiguchi, J Klasen, S Konno, SJ Ferguson, K Wuertz-Kozak
Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in vivo

Page 32: RC Pereira, A Poggi, R Benelli, D Martinelli, R Cancedda, C Gentili
Immuno-regulation by articular chondrocytes and synovial stem cells in inflammatory environment: prime effect of platelet lysate in joint repair

Page 33: SB Sesia, R Duhr, C Medeiros da Cunha, E Padovan, I Martin, A Barbero
M2-macrophages instruct mesenchymal stem/progenitor cell to better chondro-differentiate

Page 34: M Brittberg
Clinical approaches to cartilage repair

Page 35: J Mochida, D Sakai, T Watanabe, A Hiyama, T Ishii, M Tanaka, T Nukaga, Y Yamamoto
Clinical approaches to intervertebral disc repair with activated nucleus pulposus cell transplantation. A twenty-year journey from basic and translational studies to a novel clinical study

Page 36: J Lorenz, RH Straub, A Pasoldt, J Schaumburger, J Grifka, S Grässel
Norepinephrine: chondroprotective effects in human OA-chondrocytes

Page 37: D. Frisbie, HE McCarthy, CW Archer, MF Barrett, CW McIlwraith
Evaluation of articular cartilage progenitor cells for the repair of articular defects in an equine model

Page 38: S Chubinskaya, AS Levy, D Robinson, E Kon, AA Hakimiyan, L Rappoport, A Margulis, K Zaslav, P Davidson, N Altschuler
Agili-CTM Induced Cartilage Regeneration: insights in to the mode of action, in vitro and in vivo data

Page 39: M Mumme, A Barbero, S Miot, A Wixmerten, DJ Schaefer, U Studler, A Hirschmann, T Schwamborn, I Martin, M Jakob
Cartilage tissue engineering from nose to knee: early results of a phase 1 clinical trial

Poster presentations

Page 40: P Abdel-Sayed, S Rissone, DP Pioletti
The effect of fluid-dependent dissipation on chondrogenesis

Page 41: M Alaqeel, MP Grant, LM Epure, O Salem, OL Huk, J Antoniou, F Mwale
Link N suppresses Interleukin-1β induced human osteoarthritic cartilage degradation through down-regulation of NF-κB signalling

Page 42: A Basiri, G Amoo-Abedini, M Soleymani, B Khorvash, M Vasei
Cartilage growth on Insulin and collagen-coated PLGA/PCL scaffolds

Page 43: A Bertolo, A Gämperli, M Gruber, B Ritter-Gantenbein, T Pötzel, M Baur, JV Stoyanov
In vitro cell mobility: a mesenchymal stem cells marker for multipotency?

Page 44: R Bohm, S Biechler, S Williams, R Fei
Characterization of hydrogels under physiological loading conditions for cartilage tissue engineering

Page 45: A-K Born, E Despot Slade, M Zenobi-Wong
A collagen 2 reporter for online identification of chondrogenic microenvironments

Page 46: SK Both, R Wang, PJ Dijkstra, M Karperien
Injectable hydrogels for cartilage repair

Page 47: S Capossela, P Schläfli, A Bertolo, T Janner, BM Stadler, T Pötzel, M Baur, JV Stoyanov
Degenerated human intervertebral discs contain autoantibodies against extracellular matrix proteins

Page 48: S Caprez, M Peroglio, M Janki, M De Wild, LM Benneker, M Alini, S Grad
Stem cell effect on mechanically-loaded nucleotomised intervertebral discs

Page 49: SCW Chan, J Walser, SJ Ferguson, B Gantenbein-Ritter
Intervertebral disc cell response to torsion as a function of duration and magnitude

Page 50: WH Chooi, SCW Chan, B Gantenbein-Ritter, BP Chan
Expression of HSP72 and HSF1 in nucleus pulposus in response to compressive loading

Page 51: P Colombier, M Ruel, J Lesoeur, A Moreau, C Robiou-Dupont, O Hamel, L Lescaudron, J Clouet, J Guicheux
Generating nucleus pulposus-like cells from human adipose stromal cells: a first step towards the regeneration of intervertebral disc

Page 52: A Colombini, S Lopa, C Ceriani, AB Lovati, A Di Giancamillo, G Banfi, M Moretti
Behaviour of human disc cells in collagen and fibrin-based matrix

Page 53: S Diederichs, K Zachert, W Richter
Retinoid acid receptor signalling during mesenchymal stromal cell chondrogenesis: differential sensitivity of chondral versus endochondral pathways

Page 54: KS Emanuel, PPA Vergroesen, I Kingma , TH Smit
Biomechanics of the degenerating human intervertebral disc: a 10-day axial loading study

Page 55: CR Fellows, IM Khan, CW Archer
Articular cartilage contains a nestin positive stem cell population

Page 56: OFW Gardner, CW Archer, M Alini, MJ Stoddart
Comparing the secretomes of unstimulated and mechanically loaded MSCs

Page 57: E Goßla, A Bernhardt, D Aibibu, R-D Hund, A Walther, M Gelinsky
Chitosan-based flock scaffolds for potential application in tissue engineering of articular cartilage

Page 58: MP Grant, LM Epure, O Salem, O Ciobanu, M Alaqeel, J Antoniou, F Mwale
Development of a whole bovine long-term organ culture system that retains vertebral bone for intervertebral disc repair and biomechanical studies

Page 59: K-C Hung, C-S Tseng, S-h Hsu
3D printing from biodegradable polyurethane for tissue engineering applications

Page 60: LJ Kelly, SM Naqvi, CT Buckley
Microencapsulation of bone marrow derived stem cells using electrohydrodynamic spraying for minimally invasive tissue repair of the IVD

Page 61: Z Li, T Pirvu, SBG Blanquer, DW Grijpma, LM Benneker, M Alini, D Eglin, S Grad
Transplantation of bone marrow derived mesenchymal stem cells embedded in poly(trimethylene carbonate) scaffold: mechanical and biological repair of ruptured annulus fibrosus

Page 62: E Littmann, AK Solanki, H Autefage, M Alini, M Peroglio, MM Stevens
Hypoxia mimicking glasses for osteochondral tissue engineering

Page 63: RG Long, KP Cole, M Likhitpanitchkul, AC Hecht, JC Iatridis
Failure strength characterization of composite repair for annulus fibrosus injury

Page 64: B Morgan, LW Francis, RS Conlan, IM Khan
Biophysical characterisation of articular cartilage-derived stem cells using atomic force microscopy

Page 65: F Mwale, R Gawri, J Ouellet, P Önnerfjord, B Alkhatib, T Steffen, D Heinegård, PJ Roughley, J Antoniou, L Haglund
The LINK to regeneration of human intervertebral discs

Page 66: M Nassajian Moghadam, DP Pioletti
Degradation study of mechanically-controlled drug delivery system for knee cartilage

Page 67: DH Rosenzweig, B Alkhatib, E Krock, L Beckman, T Steffen, MH Weber, JA Ouellet, L Haglund
Acute mechanical injury of human intervertebral discs initiates events associated with degeneration and pain

Page 68: A Schmocker, A Khoushabi, PE Bourban, C Schizas, C Moser, DP Pioletti
Comparison of swelling properties of bovine nucleus pulposus and poly-ethylene-glycol hydrogel

Page 69: I Sitte, M Klosterhuber, V Kuhn, RA Lindtner, I Vietor, A Kathrein
Evidence of balloon cells in lumbar spine disc herniation. Preliminary morphological results of patients versus SPARC null mice

Page 70: T Studer, G Fortunato, N Gadhari, D Frauchiger, R Rossi, B Gantenbein-Ritter
Tailoring silk based nano fibres for human intervertebral disc repair

Page 71: A Tekari, R Luginbuehl, W Hofstetter, R Egli
Autonomous formation of cartilage tissue by expanded chondrocytes is dependent on a functional TGFβ-signalling

Page 72: F Tessarolo, M Fedel, R Tatti, E Bonomi, I Caola, M Molinari, P Dorigotti, G Nollo
Histochemical evaluation of second-look osteochondral biopsies: symptomatic vs. asymptomatic MACI-treated patients

Page 73: CL Thompson, A Wiles, H Yasmin, A Varone, CA Poole, MM Knight
Lithium protects cartilage from interleukin-1β induced degradation and preserves the mechanical integrity of articular cartilage

Page 74: CL Thompson, A Wiles, CA Poole, MM Knight
Lithium chloride triggers primary cilia elongation and inhibits hedgehog signalling in articular chondrocytes

Page 75: PPA Vergroesen, I Kingma, KS Emanuel, BJ van Royen, JH van Dieen, TH Smit
An explanatory model for intervertebral disc degeneration: a degenerative cycle

Page 76: KB Violin, TS Goia, K Ishikawa, JC Bressiani, AHA Bressiani
Microspheres of BCP produced by Snowballing technique for multipurpose application

Page 77: AKT Wann, JP Chapple, MM Knight
The chondrocyte primary cilium modulates NFκB signalling, defining the response to interleukin-1β

Page 78: YD Zhang, B Morgan, IM Khan
Platelet-rich plasma (PRP) induces articular cartilage maturation – A possible mechanism for repair

All abstracts: click here to download all the abstracts in one file