eCM Meeting Abstracts 2008, Collection 4
The Second International Symposium on Biotechnology in
Musculoskeletal Repair, sponsored by the AO Foundation,
2-4 October 2008, Beaulieu Convention Centre, Lausanne, Switzerland
Abstracts listed in order of presentation at the meeting
All abstracts: click here to download all the abstracts in one file
Bone and cartilage repair: Stem Cell Engineering and Genetics
Page 1: JE Aubin
Mesenchymal stem cells and osteoblast-chondroblast differentiation
Page 2: P Niemeyer, T Schönberger, J Hah
Xenogenic transplantation of human mesenchymal stem cells for treatment of critical size bone defects in sheep
Page 3: R Stange, M Timmen, T Stoltenberg, H Hidding, F Echtermeyer, K Neugebauer, T Pap, M Raschke
Syndecan-4 deficiency leads to an osteoporotic bone structure in vivo and an impaired osteoblast functionality in vitro
Page 4: T Clemens (no abstract)
Targeting the HIF-1 pathway for bone repair
Page 5: CH Evans, V Glatt, F-J Liu, JW Wells, E Ferreira, MS Vrahas, MB Harris, A Ivkovic, RM Porter
Expedited strategies for the restoration of bone
Page 6: MD Buschmann, CD Hoemann, M Hurtig, MS Shive
Chitosan-based hybrid biomaterials applied with bone marrow stimulation improves cartilage repair
Page 7: H Chen, J Sun, CD Hoemann, V Lascau-Coman, W Ouyang, L Dragomir, N Tran-Khanh, A Chevrier, MD McKee, MS Shive, MD Buschmann
A comparative study of drilling versus microfracture for cartilage repair in a rabbit model
Page 8: KMC Cheung, J Karppinen, D Chan, BJ Fan, D Ho, P Kao, Y-Q Song, P Sham, KSE Cheah, JCY Leong, KDK Luk
How has genetics research altered our understanding of Degenerative Disc Disease: Implications for intervertebral disc regeneration
Infection and its influence on healing and repair
Page 9: TW Bauer, H Kobayashi, N Kobayashi, M Oethinger, MJ Tuohy
Establishing the diagnosis of low grade infection, and the problem of identifying potential hypersensitivity reactions to metal in patients with total joint prostheses
Page 10: SAJ Zaat, CAN Broekhuizen, L de Boer, MJ Schultz, L Boszhard, AC van der Wal, CMJEVandenbroucke-Grauls
Biomaterial-associated infection: breaking out of the biofilm
Page 11: M Hook
The role of MSCRAMMs in staphylococcal skeletal infections
Page 12: MJ Raschke, T Fuchs, R Stange
Infection and osteoporosis: influence on healing and repair
Biotechnology: From bench to bedside,
Page 13: SE Lynch, C Hart, W Beasley, R Pagano
Orthopedic applications of recombinant platelet-derived growth factor
Page 14: EA Gruskin
Synthes strategy for combination devices
Page 15: M Bohner
The gap between research & clinical applications of bone substitutes
Page 16: SR Buchman
A successful paradigm for NIH funding in CMF: Enhancing translational research by expanding the network between the basic and clinical scientist. (Successful development of an interdisciplinary collaboration)
Stimulation of bone & cartilage repair
Page 17: D Mooney
Materials for angiogenesis on demand
Page 18: SR Goldring
Molecular and cellular mechanism of pathologic bone remodeling in inflammatory conditions
Page 19: K Schmidt-Bleek, H Schell, P Kolar, C Perka, F Buttgereit, G Duda, J Lienau
The cellular composition of the initial fracture and soft tissue hematoma during theinflammatory phase of the healing process
Page 20: S Otto, E Volkmer, I Drosse, KB Cherian, A Stangelmayer, M Schieker, M Ehrenfeld
Oxygen measurement in three-dimensional scaffolds for the tissue engineering of bone
Stimulation of bone & cartilage repair
Page 21: EM Schwarz
Remodeling rAAV-coated allografts for musculoskeletal repair
Page 22: JE Fong, N Cassir, D Le Nihouannen, SV Komarova
The role of osteoclasts in osteoblast regulation
Page 23: S Sauerbier, J Kuschnierz, H Nagursky, R Gutwald, R Schmelzeisen
Mesenchymal stem cells for the augmentation of the maxillary sinus
Page 24: D Le Nihouannen, SV Komarova, U Gbureck, JE Barralet
Development of brushite matrices able to stimulate bone remodelling
Page 25: FE Weber, G McKenzie, B Hardwick, B San Miguel, C Ghayor, M Ehrbar
A bioactive guided bone regeneration membrane enhances BMP signalling and tunes the natriuretic hormone system into a pro osteogenic state
Page 26: D Hutmacher (no abstract)
Tackling the challenging indications in orthopaedic surgery - application of scaffoldbased tissue engineering in osteochondral and spinal fusion models in the pig
Networking in a clinically inspired research community
Page 27: U Müller-Ladner, C Rufenach, T Pap, A Zink
The German rheumatology network
Page 28: KMC Cheung (no abstract)
The AO spine network
Page 29: J Goldhahn, N Suhm, M Blauth
The AO osteoporosis network
Animal models; which ones work in research dealing with bone and cartilage repair ?
Page 30: A Goodship
The use of rodent models in musculoskeletal research for fracture repair; a need to consider a standard?
Page 31: B von Rechenberg
Experiences with sheep models in musculoskeletal research at MSRU
Page 32: W McIIwraith
Use of equine models to evaluate articular cartilage repair
Page 33: JA Auer, A Fürst
The use of clinical patients as animal models in musculoskeletal research.
Biological markers and diagnostic tools for early disease detection.
Page 34: T Aigner, R Zimmer
System biology approaches of cartilage degeneration – a new way for understanding pathogenesis and markers
for disease monitoring ?
Page 35: D Heinegard
Molecular markers in the study of cartilage destruction in joint disease
Page 36: P Garnero
Biological markers of bone turnover
New challenges in biotechnologies for bone and cartilage
Page 37: J Kellam
What I need to do my job: Get the bone to heal!
Page 38: S Maxson, KJL Burg
The effects of conditioned media on the osteogenic and chondrogenic differentiation of mesenchymal stem cells
Page 39: M Stoddart, S Grad, B Gantenbein, S Verrier, M Alini
Stem cells for musculoskeletal regeneration
Page 40: J Vienken
Tissue engineered medical devices: Are there conditions for manufacturing and approval?
Posters
Page 41: T Anastassiades, K Rees-Milton, M Grynpas
N-acylated glucosamine derivatives for the treatment of arthritis and osteoporosis
Page 42: S Armstrong, A Pereverzev, E-j Kwon, SJ Dixon, SM Sims
Activation of P2X7 nucleotide receptors induces actin reorganization in osteoclasts
Page 43: GS Baht, GK Hunter, HA Goldberg
Bone sialoprotein-mediated mineral formation: role of phosphorylation & development of a fusion peptide for bone repair
Page 44: D Cadosch, E Chan, OP Gautschi, J Meagher, R Zellweger, L Filgueira
Titanium (IV) ions induced bone resorption due to osteoclast recruitment and activation: A human in vitro study
Page 45: CW Chan, G Li, CFF Hui, KM Lee, L Qin, YY Hu, WM Pan, KS Leung, JCY Cheng
The efficacy of low intensity pulsed ultrasound treatment on experimental spinal fusion implanted with tissue engineered composite
Page 46: SJ Dixon, N Panupinthu, J Korčok, MW Grol, SM Sims
Regulation of bone remodeling by P2X7 nucleotide receptors in osteoblasts and osteoclasts
Page 47: HA Goldberg, G Baht, J Gordon, V Pitelka, H Chen, D Holdsworth, GK Hunter
Bone repair mediated by bone sialoprotein
Page 48: A Groothuis, G Kasper, U Lehnigk, H Bail, K van Scherpenzeel, GN Duda
Angiogenic potential of the early fracture haematoma is increased by mechanical stimulation
Page 49: HE Gruber, G Hoelscher, J Ingram, B Loeffler, M Kuremsky, N Zinchenko, EN Hanley
Bioavailability of PAPP-A, the local regulator of IGF-I (insulin-like growth factor-I), in the intervertebral disc
Page 50: C Haasper, M Colditz, S Budde, T Tschernig, M Wehmeier, E Hesse, C Hurschler, C Krettek, M Jagodzinski
Osteochondral tissue engineering by implication of perfusion and cyclic compression on mesenchymal cell-loaded hybrid grafts
Page 51: T Histing, A Kristen, C Roth, JH Holstein, P Garcia, MD Menger, T Pohlemann
In vivo gait analysis in murine femoral fracture model
Page 52: M Hurtig, F David, D Fraser, B Lapostolle, A Cruz, L Fischer
BMP-7 gene therapy for mitigation of post-traumatic osteoarthritis in sheep
Page 53: G Kasper, L Mao, S Geissler, J Trippens, J Kuehnisch, C Perka, GN Duda, J Klose
Mesenchymal stem cell ageing is associated with alterations in antioxidant defense and cytoskeleton dynamics
Page 54: C Marchand, G-E Rivard, J Sun, C Hoemann
Solidification mechanisms of chitosan-glycerol phosphate/blood implant for articular cartilage repair
Page 55: OM Maria, SV Komarova
Intercellular propagation of signal induced by mechanical stimulation of a single bone marrow cell
Page 56: DD McErlain, V Pitelka, JL Henry, DW Holdsworth
Investigating the effects of OA on rodent knee vasculature using contrast enhanced micro-computed tomography
Page 57: W Metzger, N Grenner, R Strehlow, T Pohlemann, M Oberringer
Normal human dermal fibroblasts differentiate into contractile myofibroblasts after contact with bioactive surfaces
Page 58: M Oberringer, C Meins, M Bubel, T Pohlemann
Transforming growth factor β1 does not attenuate the hypoxia induced response of fibroblasts and endothelial cells
in a new in vitro co-culture wound healing model
Page 59: A Quintin
Fetal spine cells: A potential cell source fort intervertebral disc regeneration?
Page 60: MD Ryser, N Nigam, SV Komarova
Impact of the spatial RANKL/OPG distribution on BMU branching
Page 61: J Smedeck, F Otto, K Pöpperl, J Kuschnierz, J Haberstroh, R Gutwald, R Schmelzeisen, E Sachlos, S Sauerbier
Collagen-hydroxyapatite scaffolds for bone engineering
Page 62: SM Sims, S Armstrong, A Pereverzev, SJ Dixon
P2X7 receptor activation causes isoform-specific translocation of protein kinase C in osteoclasts
Page 63: FE Weber, MP Lutolf, S Rizzi, J Hubbell, M Ehrbar
Bone tissue engineering using synthetic fibrin-like hydrogels
Page 64: K Wuertz, K Godburn, J Iatridis
Mesenchymal stem cell response to a pH challenge with applications to intervertebral disc repair
Page 65: C Yang, H Frei, HM Burt, FM Rossi
Rat bone marrow stromal cells differentiation and proliferation: Effects of continuous and pulsatile parathyroid hormone treatments
Page 66: Th Ziebart, MO Klein, J Adler, H Goetz, M Grez, W Wagner, H Duschner, B Al-Nawas
Investigation of three different labelling techniques to visualize vital cells
Page 67: S Sauerbier, J Kuschnierz, H Nagursky, R Gutwald, R Schmelzeisen
Mesenchymal stem cells for the augmentation of the maxillary sinus
Page 68: S Elsler, S Schetting, D Kohn, H Madry, M Cucchiarini
Comparative gene transfer analysis in human mesenchymal stem cells using 15 novel optimized non-viral transfection systems
Page 69: J Eyckmans, J Schrooten, FP Luyten
Hydroxyapatite, BMP and Wnt signaling are required in cell based ectopic bone formation
Page 70: H Hofmann, A Fink-Petri, J Salaklang, V Bernau
Nanotechnology for medical application: Potential, challenges and results
Page 71: G Nourissat, A Diop, N Maurel, M Gosset, F Berenbaum
Use of cell therapy to enhance the bone tendon healing, validation of a small animal model and results with the use of chondrocytes in rat.
Page 72: S Miettinen, B Lindroos, K Mesimäki, J Törnwall, R Suuronen
Microvascular bone reconstruction with induction of ectopic bone formation by multipotent human adipose stem cells - case report
Page 73: M Timmen, B Wieskötter, H Hidding, J Everding, M Peters, B Eckes, T Pap, M Raschke, R Stange
Integrin α2: deficiency causes impaired bone stability in vivo and reduced mineralization of the extracellular matrix in vitro
Page 74: D Docheva, D Padula, S Poppe, P Weishaupt, C Popov, M Schieker
Generation of human tendon- and ligament-derived cell lines, via immortalization with hTERT, for tissue engineering applications
Page 75: F Mwale, HT Wang, P-L Girard-Lauriault, MR Wertheimer, J Antoniou, A Petit
Mechanism of decreased expression of type X collagen in human mesenchymal stem cells from osteoarthritis patients cultured on nitrogen-rich plasma polymers: Implication of cyclooxygenase-1
Page 76: C Kähling, C Seebach, D Henrich, I Marzi
Early vascularization and new bone formation in a critical bone defect is improved by co-culture of endothelial progenitor cells (EPC) and mesenchymal stem cells (MSC) in rats
Page 77: N Rosenberg
Extracorporal bone generation
Page 78: Y Chun, A Usas, A Ho, H Peng, J Huard
Time-dependent VEGF expression modulates ectopic bone formation mediated by muscle-derived stem cells
Page 79: A Hofmann, U Ritz, S Verrier, D Eglin, M Alini, S Fuchs, CJ Kirkpatrick, PM Rommens
Human osteoblasts induce proliferation and neo-vessel formation of human umbilical vein endothelial cells in a long-term 3D co-culture on polyurethane scaffolds
Page 80: JK Jackson, S Tredwell, F Leung, C Duncan, HM Burt
Controlled release of antibiotics from bone cement.
Page 81: L Poveda, K Wuertz, M Hottiger, N Boos
Impact of peroxynitrite on intervertebral disc cells
All abstracts: click here to download all the abstracts in one file